Analytical Gaps and Challenges for Particles in the Submicrometer Size Domain

Aldrich S, Cao S, Hawe A, Hunt D, Narhi L, Ripple D, Singh SK

This Stimuli article provides a technical discussion of the available technologies for submicrometer particle analysis, including consideration of the advantages, disadvantages, and technical gaps for each application. These methods can be used in the characterization of different protein aggregates as well as other types of particles in this size range. Changes are occurring rapidly in this field, so the Stimuli article and discussions focus on measurement principles and comparisons rather than specific instruments.

Pharmac. Forum