Vaccine development services from the scientific expert
Vaccines are a diverse drug product category with one common goal: modulate the immune system in order to prevent infectious diseases, fight cancer or induce tolerance against allergens. They work by presenting highly specific antigens, combined with stimuli for the innate immune system (adjuvants) to the immune system in order to stimulate or inhibit (in the case of allergy vaccines) an immune response. In a best case, vaccines induce long-lasting effects without the need for frequent re-immunization.
Vaccines are especially successful in preventing or reducing the severity of infectious diseases including measles, polio, and Covid-19, and have successfully eradicated smallpox. In a more experimental setting cancer vaccination shows promise as a new tumor therapy.
Prophylactic and therapeutic vaccines
Prophylactic vaccines aim to prevent or reduce the severity of infectious diseases and – if a sterilizing immunity is achieved - inhibit further spreading. Since prophylactic vaccines are administered to healthy individuals, they are expected to fulfill very high quality and safety standards. Therapeutic vaccines aim to treat patients with existing diseases such as various types of cancer. This is an exciting field of research with the potential to address currently unmet medical needs. Also, therapeutic exposure to allergens is a form of vaccination with the aim to induce immune tolerance.
Coriolis is your expert partner
Coriolis is a science driven research organization with a problem-solving mindset and a quick turnaround time. We provide highly flexible and tailor-made solutions for the development of modern vaccine products. With many years of experience in vaccine development and a large portfolio of analytical techniques, Coriolis is your expert partner for formulation development and analytical characterization projects. With distinguished vaccine experts on our scientific advisory board, we can give professional advice on the most suitable vaccine formulation development strategy. We support the development of all vaccine types including:
- mRNA vaccines (for more than 10 years already)
- viral vector vaccines
- live-attenuated virus vaccines
- subunit vaccines including virus like particles
Specialized services for your vaccine product
Coriolis science-driven solutions are based on our deep understanding of the specific challenges of developing a vaccine. Our expert scientists will devise dedicated study designs tailored to the needs of your product and development phase.
Development of adjuvanted vaccines
Sub-unit vaccines often need an adjuvant to activate the innate immune system. Adjuvants are a heterogeneous group of molecules and particles (delivery systems) and their presence and interaction with antigens may hamper the characterization of the vaccine.
Our scientific experts are experienced in performing development studies for adjuvanted vaccines with a focus on the quantification of adjuvant-bound and free vaccine, the adsorption capacity, and the desorption profile.
Analytical methods for low concentration samples
The concentration of antigen in vaccine drug products is typically in the microgram range and low compared to most therapeutic protein-based biologics. Also, the presence of adjuvants in many sub-unit vaccines may hamper analytical characterization.
Coriolis is highly experienced in developing analytical methods for low concentrated vaccines and complex samples, such as adjuvanted vaccines. With our large portfolio of analytical techniques, we generate a comprehensive picture of your vaccine sample.
Development services for your vaccine product
Explore our large portfolio of development services. In a unique collaborative approach, we individually design each study to meet your expectations and the needs of your current development phase. You will benefit from the scientific experience and advise of our expert scientists to achieve your development goals faster and with a higher chance of success.
Analytical services for your vaccine product
Choose from a large set of analytical techniques in a variety of categories or get our expert opinion on the most suitable methods for your analytical challenge. We offer standardized analytical methods for many common sample types and perform dedicated method development specific for your analytical challenge and drug product. Explore our analytical portfolio ranging from discovery phase analysis to lot release testing methods.
Our know-how related to vaccines
Coriolis is a science-driven service provider. We perform internal research projects with academic and industrial partners to develop new technologies and create in-depth knowledge, which directly benefits our client projects. Our internal Unit Science & Technology, hosting PhD candidates and Postdocs, also actively contributes to the scientific community with numerous peer-reviewed publications each year. Explore our latest publications, articles, and webinars.
Other product types
We tailor our services to your specific product type and development phase. In a unique collaborative approach, our expert scientists focus on your scientific question or development milestone and support your drug development program with their many years of experience. Select your product type to learn more about our services.