Particle Analysis in Biopharmaceuticals: An Overview from Protein Particles to Living Cells

Particle Analysis in Biopharmaceuticals: An Overview from Protein Particles to Living Cells

In this webinar, Dr. Tim Menzen introduces you to the broad field of particle characterization for biopharmaceuticals. He outlines the various types of particles relevant in biopharmaceutical industry, ranging from impurities and degradation products like protein aggregates to particulate formulations such as viral vectors and living cells. His talk further presents analytical tools available for the characterization of particles in various size ranges. On the example of real case studies, Dr. Menzen describes, how a broad analytical portfolio of orthogonal methods is used for the reliable sizing, quantification, differentiation and identification of particles in the nanometer, micrometer and visible size range.

LEARNING OBJECTIVES

• the various types of particles relevant for the biopharmaceutical industry
• different analytical techniques and their applications during drug product development
• the portfolio of analytical tools relevant for biopharmaceutical applications
• the results of 3 case studies solving important analytical challenges:
  • Differentiation of protein aggregates from silicone oil droplets
  • Quantification of empty vs. full capsids in AAV samples
  • Identifying impurities in cell-based medicinal products