Drug delivery system

Developing your therapeutic compound with targeted delivery and controlled release

Developing your therapeutic compound with targeted delivery and controlled release

Drug delivery systems enable a molecule to reach its intended target and release it for therapeutic effect. Drug delivery systems are often employed, when a molecule cannot reach the target by itself, when a compound may undergo degradation or system clearance after application, when side effects due to off-target toxicity are an issue, or when a controlled release of the drug substance is desired. Drug delivery systems are used during the development of novel drug products but are also employed to reformulate and optimize existing therapies.

Coriolis is your expert partner for developing robust and phase-appropriate formulations for drug delivery systems. We perform stability and forced degradation studies and provide reliable and sensitive analytical data on the stability of your drug delivery system.

Nanoparticulate delivery systems

A number of different nanoparticulate delivery systems are available for pharmaceutical application, including exosomes, liposomes, polymeric or lipid nanoparticles, lipoplexes and dendrimers. They are usually employed for parenteral applications and are typically in the nanometer size range. Viral vectors may also fall under the category of delivery systems as they carry nucleic acids into cells. To learn more about our services related to viral vectors, please visit this page.

For the characterization of nanoparticulate delivery systems, we employ a large portfolio of cutting-edge particle analysis techniques and use our strong scientific background in this field to obtain sensitive and robust analytical methods specific for you drug product. Our expert scientists also develop stable and phase-appropriate drug product formulations for your drug delivery system-based therapeutic.

The payload of drug delivery systems

The drug substance inside a drug delivery system should remain stable and effective until delivery at the target site. Analytical characterization and stabilization of the payload may be a challenge of its own. To learn more about our services, please visit our pages on therapeutic proteins, peptides, and nucleic acids.

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Our experts are happy to discuss how we can support the development of your drug delivery system-based product.

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Specialized services for your drug delivery system

Coriolis offers science-driven solutions and considers the specific challenges of developing a drug delivery system. Our expert scientists develop a dedicated study design tailored to the needs of your drug delivery system, product type and development phase.


Analytical development for API recovery assessment

Characterization of the API within a drug delivery system requires the separation of the API from the drug delivery system. Our scientific experts develop disruption protocols to recover e.g., mRNA from LNPs, and enable a separate analytical characterization of delivery system and payload.

Of course, we also develop analytical methods using for broad set of analytical techniques to assess the integrity and stability of the API after recovery.


Characterizing particle size distributions of nanoparticulate delivery systems

Particles in the nanometer size range are notoriously difficult to characterize. Yet, the size distribution, concentration and morphological characteristics are crucial parameters to assess the stability and integrity of a drug delivery system.

Coriolis has a strong scientific background in particle analysis. We employ state-of-the-art and emerging analytical techniques for a comprehensive and orthogonal characterization of even the most challenging particulate samples. Our scientists continuously try and implement new technologies and analytical approaches. This way, we can put together the most suitable set of instruments for your analytical challenge.

Development services for your drug delivery system

Explore our large portfolio of development services. In a unique collaborative approach, we individually design each study to meet your expectations and the needs of your current development phase. You will benefit from the scientific experience and advise of our expert scientists to achieve your development goals faster and with a higher chance of success.

Analytical services for your drug delivery system

Choose from a large set of analytical techniques in a variety of categories or get our expert opinion on the most suitable methods for your analytical challenge. We offer standardized analytical methods for many common sample types and perform dedicated method development specific for your analytical challenge and drug product. Explore our analytical portfolio ranging from discovery phase analysis to lot release testing methods.

Our know-how related to drug delivery systems

Coriolis is a science-driven service provider. We perform internal research projects with academic and industrial partners to develop new technologies and create in-depth knowledge, which directly benefits our client projects. Our internal Unit Science & Technology, hosting PhD candidates and Postdocs, also actively contributes to the scientific community with numerous peer-reviewed publications each year. Explore our latest publications, articles, and webinars.

Knowledge items

Other product types

We tailor our services to your specific product type and development phase. In a unique collaborative approach, our expert scientists focus on your scientific question or development milestone and support your drug development program with their many years of experience. Select your product type to learn more about our services.

Let's talk!

Our experts are happy to discuss how we can support the development of your drug delivery system-based product.

Get in contact

Contact us

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Please contact Dr. Jörg Müller for inquiries related to drug delivery systems

Dr, Jörg Müller