Maximum Quality at Maximum Speed: A Novel Approach to Freeze-Drying Cycle Design

Maximum Quality at Maximum Speed: A Novel Approach to Freeze-Drying Cycle Design

In this webinar, Prof. Wolfgang Friess introduces you to the field of pharmaceutical freeze-drying with a focus on process design. He outlines the critical phases of a freeze-drying cycle and present the impact of formulation aspects and process settings on the product quality.

Next, Dr. Brecht Vanbillemont elaborates on a novel freeze-drying cycle design approach recently established at Coriolis Pharma. The approach applies a design space of the primary drying phase, which guarantees maximum product quality. Dr. Vanbillemont explains the major sources of process variability in the primary drying phase and will apply that knowledge to design robust protocols. He showcases the model-based optimization strategy by presenting two distinct case studies.

Learning objectives

• the basic aspects of lyophilization/freeze-drying process
• the impact of formulation and process settings on product quality
• sources of variability in the lengthy primary drying phase
• a novel strategy established at Coriolis Pharma to design robust and fast cycles