Our staff members have contributed to a number of scientific publications before and during their association with Coriolis. This combined knowledge is the backbone of our scientific excellence. If you are interested in reprints of the publications, please feel free to contact us.
Our most recent publications are listed below by default. Please make use of the drop-down filter to explore all our papers by year of publication or highlight some award winning key publications.
J Pharm Sci. (2017)
Trends on Analytical Characterization of Polysorbates and their Degradation Products in Biopharmaceutical Formulations
Martos A , Koch W , Jiskoot W , Wuchner K , Winter G , Friess W , Hawe A
Among many other applications, polysorbates (PS) are used as the most common surfactants in biopharmaceutical products in particular to protect proteins against interfacial stress. Structural heterogeneity, presence of degradants and other impurities, and tendency for degradation are interrelated features found in commercial PS with a direct impact on their functional properties in biopharmaceutical products. These pose a challenge for the analytical characterization of PS at different stages of product development. This review article focuses on methods and strategies reported in the recent years for the analytical characterization of PS, their degradants and other impurities within neat PS (i.e., PS raw materials), diluted PS solutions, as well as in biopharmaceutical formulations. The use of versatile and complementary methods applied in a systematic approach is crucial to understand the impact of the concentration, composition and degradation of PS on the quality of biopharmaceutical products.