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Drug Product Development
Analytical Services
Manufacturing Support
Your Product
About Coriolis
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OVERVIEW
Formulation development
Lyophilization process development
Forced degradation studies
Stability studies
In-use stability studies
Preformulation studies
Comparability studies
Overview
Aggregate analytics
Aggregate analytics – Overview
Analytical ultracentrifugation (SV-AUC / SE-AUC)
Asymmetrical flow field-flow fractionation (AF4)
Capillary gel electrophoresis (cGE)
Dynamic light scattering (DLS)
High performance size-exclusion chromatography (HP-SEC)
Hollow fiber flow field-flow fractionation (HF5)
Liquid chromatography coupled mass spectrometry (LC-MS)
Nephelometry / Turbidity
SDS-PAGE
Ultra-high-performance size-exclusion chromatography (UP-SEC)
Particle characterization
Particle Characterization – Overview
Asymmetrical flow field-flow fractionation (AF4)
Backgrounded membrane imaging (BMI)
Dynamic light scattering (DLS)
Electrical sensing zone (ESZ) / microfluidic resistive pulse sensing (MRPS)
Micro-Flow Imaging (MFI)
Hollow fiber flow-field-flow fractionation (HF5)
Imaging flow cytometry (IFC)
Light microscopy (LM)
Light obscuration (LO)
Nanoparticle tracking analysis (NTA)
Nephelometry / Turbidity
Quantitative laser diffraction (qLD)
Resonant mass measurement (RMM)
Semi-automated visual inspection (SAVI)
Transmission electron microscopy (TEM)
Visual inspection
Particle identification
Fourier transform infrared (FTIR) microscopy
Raman microscopy
Scanning electron microscopy coupled energy-dispersive x-ray spectroscopy (SEM-EDS)
Surfactant characterization
Surfactant characterization – Overview
Liquid chromatography coupled mass spectrometry (LC-MS)
Liquid chromatography with charged aerosol detection (LC-CAD)
Higher order structure analysis
Higher Order Structure – Overview
Circular dichroism (CD)
Differential scanning calorimetry (µDSC)
Dynamic Light Scattering (DLS)
Fluorescence spectroscopy
Fourier transform infrared (FTIR) spectroscopy
High performance size-exclusion chromatography (HP-SEC)
Liquid chromatography coupled mass spectrometry (LC-MS)
Nano differential scanning fluorimetry (nanoDSF / nDSF)
Functional assays
Surface Plasmon Resonance (SPR)
Virus titration / TCID50 assay
Chemical changes
Chemical Changes – Overview
Capillary isoelectric focusing (cIEF)
Ion-exchange chromatography (IEX)
Liquid chromatography coupled mass spectrometry (LC-MS)
Reversed-phase chromatography (RP-HPLC / RP-UPLC)
Lyophilizate analytics
Headspace moisture analysis (HMA)
Freeze-drying microscopy (FDM)
Differential scanning calorimetry (DSC)
Karl-Fischer titration (KFT)
Gas adsorption analysis based on the Brunauer–Emmett–Teller (BET) theory
X-ray powder diffraction (XRD)
Container closure & integrity testing
Basic formulation characterization
OVERVIEW
Liquid drug products
Lyophilized drug products
OVERVIEW
Antibody or related product
ATMPs
Cell therapy product
Drug delivery system
Gene therapy product
Nucleic acid
Peptide
Small molecule
Therapeutic protein
Vaccine
Viral vector
OVERVIEW
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