Biophysical and biochemical characteristics of therapeutic proteins.

2019

Pharmaceutical Biotechnology, 5th edition (Crommelin DJA, Sindelar RD, and Meibohm B, Eds.)

Jiskoot W and Crommelin DJA.

Pharmaceutical proteins are large, folded structures stabilized by weak physical/chemical forces. An appreciation of the factors that may influence their structure is an absolute requirement when dealing with these complex, fragile compounds.

Pharmaceutical Biotechnology, 5th edition (Crommelin DJA, Sindelar RD, and Meibohm B, Eds.)

https://link.springer.com/chapter/10.1007/978-3-030-00710-2_2

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NEW PUBLICATION: High throughput multidimensional liquid chromatography approach for online protein removal and characterization

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Use of Closed System Transfer Devices (CSTDs) with Protein-Based Therapeutic Drugs—A Non-Solution for a Non-Problem?

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Genome length determination in adeno-associated virus vectors with mass photometry

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Possibilities and limitations of α-relaxation data of amorphous freeze-dried cakes to predict long term IgG1 antibody stability

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Three-Dimensional Homodyne Light Detection (3D-HLD) for High-Throughput Submicron Particle Analysis in (Highly Concentrated) Protein Biopharmaceuticals, Viral Vectors, and LNPs

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Reversed phase liquid chromatography for recombinant AAV genome integrity assessment

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