Biophysical and biochemical characteristics of therapeutic proteins.

Jiskoot W and Crommelin DJA.

Pharmaceutical proteins are large, folded structures stabilized by weak physical/chemical forces. An appreciation of the factors that may influence their structure is an absolute requirement when dealing with these complex, fragile compounds.

Pharmaceutical Biotechnology, 5th edition (Crommelin DJA, Sindelar RD, and Meibohm B, Eds.)

https://link.springer.com/chapter/10.1007/978-3-030-00710-2_2