Robustness testing, scale-up and transfer
A robust and scalable process ensures a smooth transfer
The transfer of a lyophilization cycle from Coriolis to the manufacturing site of our clients is a crucial step during development. Thus, our scientists designing and developing freeze-drying cycles to be robust and scalable, allowing for a smooth process transfer.
Coriolis operates a 400 m² lyophilization development center with freeze-dryers of various sizes and drying capacities. This allows our scientists to perform freeze-drying cycle development at lab-, pilot- and production-scale, while optimizing processes for scale-up already at an early development stage.
From the very beginning of process development, our experts consider the key variables of the lyophilization process that enable a later scale-up and transfer to the production facilities of our customer.
Our freeze-dryers are equipped with a broad range of the latest in process analytical technology to comprehensively understand all important process characteristics. Also, our scientists utilize a portfolio of dedicated lyo analytics for product characterization.