Robustness testing, scale-up and transfer

lyophilization_development

Ensuring a smooth process transfer

The transfer of a lyophilization cycle developed at Coriolis to the manufacturing site of our customers is a crucial step and requires the process to be robust and scalable.

To guarantee a smooth transition, Coriolis Pharma is equipped with freeze-dryers of various sizes and drying capacities. These allow our scientists to perform freeze-drying cycle development at lab-, pilot- and production-scale, while optimizing processes for scale-up already at an early development stage. From the very beginning of process development our experts consider the key variables of the lyophilization process that enable a later scale-up and transfer to the production facilities of our customer.

Our freeze-dryers are equipped with a broad range of the latest in process analytical technology to comprehensively understand all important process characteristics.