Coriolis Scientist speaks at virtual CASSS Higher Order Structure Event
Symposium on the Higher Order Structure of Protein Therapeutics
Protein higher order structure (HOS) includes the secondary, tertiary and quaternary structures of a protein, which comprise the three dimensional structures that are necessary for structure and function. Proteins in solution are dynamic molecules which can sample an ensemble of structures in solution, and have molecular properties which results in differing propensities to self associate and form a range of species from oligomers to visible particles. There are many biophysical characterization methods and tools used in monitoring the attributes of protein therapeutics such as conformation and higher order structure.
Use of the appropriate biophysical method, method development and qualification to characterize the quality attributes at different stages of the product lifecycle are therefore a matter of interest and debate for a wide range of audiences. This CASS HOS symposium will focus on various biophysical methods for assessment of protein HOS, as well as the applications of the appropriate tools during the different stages of protein therapeutic development and biosimilarity assessments, the theory and practice of biophysics, technical data from academia and industry as well as method qualification, validation and setting specifications.
Coriolis Scientist gives talk about High-Throughput Characterization of Subvisible Particles
Dr. Constanze Helbig will introduce Backgrounded Membrane Imaging (BMI), a valuable technique for high-throughput characterization of subvisible particles, and will share exciting results and insights on how to utilize BMI during biopharmaceutical drug product development. Her talk will take place on 12 April 2021 at 10:00 during session 1. She will be approachable throughout the event and she is looking forward to many engaging discussions and valuable virtual meetings.
To register for the event - click here